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485 Oligoneuronal Hypoganglionosis in Patients with Idiopathic Slow-Transit Constipation [2002년 1월 DCR] 2011-11-17 1701
 
T. Wedel, M.D., U. J. Roblick, M.D., V. Ott, M.D., R. Eggers, M.D., T. H. K. Schiedeck, M.D., H.-J. Krammer, M.D., H.-P. Bruch, M.D.

From the Departments of Anatomy and Colorectal Surgery, Medical University of Lu¨ beck, Lu¨ beck,
Germany, and the ‡Department of Gastroenterology, Medicine II, University of Heidelberg at Mannheim,
Mannheim, Germany
PURPOSE: Several alterations of the enteric nervous system have been described as an underlying neuropathologic correlate in patients with idiopathic slow-transit constipation. To obtain comprehensive data on the structural components of the intramural nerve plexus, the colonic enteric nervous system was investigated in patients with slowtransit constipation and compared with controls by means of a quantitative morphometric analysis.
METHODS: Resected specimens were obtained from ten patients with slow-transit constipation and ten controls (nonobstructive neoplasias) and processed for immunohistochemistry with the neuronal marker Protein Gene Product 9.5. The morphometric analysis was performed separately for the myenteric
plexus and submucous plexus compartments and included the quantification of ganglia, neurons, glial cells, and nerve fibers.
RESULTS: In patients with slow-transit constipation, the total ganglionic area and neuronal number per
intestinal length as well as the mean neuron count per ganglion were significantly decreased within the myenteric plexus and external submucous plexus. The ratio of glial cells to neurons was significantly increased in myenteric ganglia but not in submucous ganglia. On statistical analysis, the histopathologic criteria (submucous giant ganglia and hypertrophic nerve fibers) of intestinal neuronal dysplasia
previously described in patients with slow-transit constipation were not completely fulfilled. CONCLUSION: The colonic motor dysfunction in slow-transit constipation is associated with quantitative alterations of the enteric nervous system. The underlying defect is characterized morphologically by oligoneuronal hypoganglionosis. Because the neuropathologic alterations primarily affect the myenteric plexus and external submucous plexus, superficial submucous biopsies are not suitable to detect these innervational disorders.